在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Nicotinate phosphoribosyltransferase (NAPRT), partial

  • 中文名稱:
    人NAPRT重組蛋白
  • 貨號:
    CSB-BP015451HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人NAPRT重組蛋白
  • 貨號:
    CSB-EP015451HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人NAPRT重組蛋白
  • 貨號:
    CSB-MP015451HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    NAPRT
  • Uniprot No.:
  • 別名:
    FHA HIT interacting protein; FHA-HIT-interacting protein; FHIP; NAPRT1; NAPRTase; Nicotinate phosphoribosyltransferase; Nicotinate phosphoribosyltransferase domain containing 1; Nicotinate phosphoribosyltransferase domain-containing protein 1; Nicotinic acid phosphoribosyltransferase; PNCB_HUMAN; PP3856
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 表達區域:
    229-538aa
  • 氨基酸序列
    MLAPAAGEGPGVDLAAKAQVWLEQVCAHLGLGVQEPHPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAQEIRKVFRAAAAQFQVPWLESVLIVVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGGVYKLVAVGGQPRMKLTEDPEKQTLPGSKAAFRLLGSDGSPLMDMLQLAEEPVPQAGQELRVWPPGAQEPCTVRPAQVEPLLRLCLQQGQLCEPLPSLAESRALAQLSLSRLSPEHRRLRSPAQYQVVLSERLQALVNSLCAGQSP
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.
  • 基因功能參考文獻:
    1. No correlation between IDH1/2 mutation status and sensitivity for NAMPT inhibitors was observed. Strikingly, higher methylation of the NAPRT promoter was observed in high-grade versus low-grade chondrosarcomas. In conclusion, this study identified NAMPT as a potential target for treatment of chondrosarcoma PMID: 28860121
    2. Synthesis and Degradation of Adenosine 5'-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases PMID: 28416276
    3. High NAPRTase expression is associated with neoplasms. PMID: 26675378
    4. Tumor-specific promoter hypermethylation of NAPRT1 inactivates one of two NAD salvage pathways, resulting in synthetic lethality with the coadministration of a NAMPT inhibitor. PMID: 24097869
    5. Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner PMID: 22570471
    6. NAPRT expression was varied in lymphomas with 30-50% low expression except for Hodgkin's lymphoma where 85% displayed low expression PMID: 21492230
    7. NA elevates cellular NAD levels through NAPRT function and, thus, protects the cells against stress, partly due to lack of feedback inhibition of NAPRT but not NamPRT by NAD PMID: 17604275

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytosol.
  • 蛋白家族:
    NAPRTase family
  • 數據庫鏈接:

    HGNC: 30450

    OMIM: 611552

    KEGG: hsa:93100

    STRING: 9606.ENSP00000401508

    UniGene: Hs.493164



主站蜘蛛池模板: 国产午睡沙发被弄醒完整版| 少妇高潮无套内谢| 亚洲精品一区二区不卡| 黑人与中国少妇xxxx视频| 成人美女黄网站色大免费的| 国产肉体ⅹxxx137大胆| 国产女人高潮嗷嗷嗷叫| 免费人成黄页在线观看国产| 欲香欲色天天综合和网| 欧美人做人爱a全程免费| 亚洲国产成人极品综合| 丰满人妻熟妇乱又伦精品app| 香蕉视频在线精品视频| 内射老妇bbwx0c0ck| 久99久热只有精品国产女同| 亚洲国产精品成人精品无码区| 少妇被躁爽到高潮无码文| 精品夜夜澡人妻无码av蜜桃| 久久久久日韩精品免费观看| 亚洲深深色噜噜狠狠网站| 97人妻天天摸天天爽天天| 无码无遮挡又大又爽又黄的视频| 欧美制服丝袜人妻另类| 日本特黄aaaaaa大片| 国产亚洲精品一区二区三区| 亚洲熟妇中文字幕日产无码| 精品日韩亚洲欧美高清a| 国产成人无码一二三区视频| 蜜臀aⅴ国产精品久久久国产老师| 五月婷婷之综合缴情| 国产乱码二卡3卡四卡| 亚洲色偷精品一区二区三区| 强被迫伦姧惨叫人妻系列| 久久天天躁夜夜躁狠狠躁| 亚洲性啪啪无码av天堂| 日韩伦人妻无码| 人妻无码系列一区二区三区| 亚洲国产成人无码av在线| 人妻在客厅被c的呻吟| 少妇无码av无码一区| 曰批免费视频播放免费|